DTscore Stable

DTscore - A distance based tandem duplication tree reconstruction algorithm.

A distance based tandem duplication tree reconstruction algorithm.

DTscore application was developed to be a distance based tandem duplication tree reconstruction algorithm. It is based on a simple tandem duplication model, which assumes unequal recombination (crossover) as the only duplication mechanism.

All it takes as input is a distance matrix between copies. In this matrix, the rows and columns need to be ordered in the same way as the copies are ordered on the locus. DTscore can be applied to relatively large datasets (more than a hundred copies).

Distances can be calculated using programs such as DNADIST (nucleotide sequences) or PROTDIST (protein sequences) from the PHYLIP package. Heterogeneous rates of substitution among sites can be dealt with using the GAMMA method, for example.

DTscore Stable is licensed as Freeware for the Windows operating system / platform. DTscore is provided as a free download for all software users (Freeware).